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Mite allergen control with acaricide fails.

AUTHORS: Huss RW; Huss K; Squire EN Jr; Carpenter GB; Smith LJ; Salata K; Hershey J
AFFILIATION: Allergy/Immunology Service, Walter Reed Army Medical Center, Washington, D.C.
SOURCE: J Allergy Clin Immunol 1994 Jul; 94(1): 27-32
CITATION IDS: PMID: 8027495 UI: 94299996
ABSTRACT:

BACKGROUND: We compared the effects of an acaricide, benzyl benzoate, with the effects of baking soda control applied to bedroom and living room carpets on house dust mite allergen levels, lung function, and medication use in 12 adult patients with asthma for 12 months.
METHODS: This was a randomized, double-blind, placebo-controlled study. Patients were enrolled from the allergy clinic of a large tertiary care center in a metropolitan area. All patients had positive dust mite puncture test results. Six patients used benzyl benzoate, and six used baking soda. Other aggressive mite control measures were implemented uniformly in each group. Subjects were to make two carpet applications, at baseline and at 6 months according to the manufacturer's recommendations. Dust samples were collected in bedroom and living room carpets at 0, 3, 6, 9, and 12 months; and quantities of Der p I and Der f I allergens were determined. Spirometry was done every 3 months, and peak flow rates were recorded for 10 days after each dust sampling.
RESULTS: There were no significant differences in mean allergen levels between the two groups over time at either site. There were no significant changes in lung function or medication use for either group.
CONCLUSION: Benzyl benzoate powder applications may not be effective when done according to manufacturer's instructions. Further studies are necessary to test effectiveness when applied more frequently and for longer periods.

 

Clinical effects of benzyl benzoate in the prevention of house-dust- mite allergy. Results of a prospective, double-blind, multicenter study.

AUTHORS: Kroidl RF; Gobel D; Balzer D; Trendelenburg F; Schwichtenberg U
AFFILIATION: Wissenschaftliche Arbeitsgemeinschaft fur die Therapie von Lungenkrankheiten, (Scientific Study Group for the Therapy of Lung Diseases).
SOURCE: Allergy 1998 Apr;53(4):435-40
CITATION IDS: PMID: 9574889 UI: 98234188
ABSTRACT: The efficacy of the acaricide benzyl benzoate as an additive to a chemically and technically defined cleaning substance (Acarosan) was tested in a multicentric, prospective, randomized, controlled study on 118 outpatients with bronchial asthma due to house-dust-mite allergy. Subjective reports from patients and doctors revealed an improvement in clinical complaints in more than 50%, with only small differences between the verum and the placebo group. Objective parameters such as titrated skin tests, RAST, and bronchial challenge tests with histamine and Dermatophagoides pteronyssinus (D. pt.) did not reveal any significant changes either during the year of testing or between the two groups. A clinical improvement as observed in either group could not be assessed by objective parameters. Additional questions as to the merits of the possible prophylactic use of benzyl benzoate over more than 1 year remain unanswered.